8.2.3 Relative Biological Effectiveness in Carbon-Ion Therapy
نویسندگان
چکیده
منابع مشابه
Basics of particle therapy II: relative biological effectiveness
In the previous review, the physical aspect of heavy particles, with a focus on the carbon beam was introduced. Particle beam therapy has many potential advantages for cancer treatment without increasing severe side effects in normal tissue, these kinds of radiation have different biologic characteristics and have advantages over using conventional photon beam radiation during treatment. The re...
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In radiation therapy, ions heavier than proton have more biological advantages than a proton beam. Recently, ion helium has been considered due to high linear energy transfer (LET) to the medium and a higher relative biological effect (RBE). To design the spread-out Bragg peak (SOBP) of biological dose for radiation with any type of ion, we need exact values of RBE, which is dependent to dose, ...
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BACKGROUND Aim of this study was to evaluate the relative biological effectiveness (RBE) of carbon (12C) and oxygen ion (16O)-irradiation applied in the raster-scanning technique at the Heidelberg Ion beam Therapy center (HIT) based on clonogenic survival in hepatocellular carcinoma cell lines compared to photon irradiation. METHODS Four human HCC lines Hep3B, PLC, HepG2 and HUH7 were irradia...
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Carbon-ion radiotherapy (CIRT) holds promise to treat inoperable locally-advanced non-small cell lung carcinoma (NSCLC), a disease poorly controlled by standard chemoradiotherapy using X-rays. Since CIRT is an extremely limited medical resource, selection of NSCLC patients likely to benefit from it is important; however, biological predictors of response to CIRT are ill-defined. The present stu...
متن کاملA mechanism-based approach to predict the relative biological effectiveness of protons and carbon ions in radiation therapy.
PURPOSE The physical and potential biological advantages of proton and carbon ions have not been fully exploited in radiation therapy for the treatment of cancer. In this work, an approach to predict proton and carbon ion relative biological effectiveness (RBE) in a representative spread-out Bragg peak (SOBP) is derived using the repair-misrepair-fixation (RMF) model. METHODS AND MATERIALS Fo...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 2019
ISSN: 0033-8303,1884-4111
DOI: 10.3769/radioisotopes.68.701